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These effects explain why GLP-1 receptor agonists are useful for both type 2 diabetes and chronic weight management

Some of the DPP-4 inhibitors are substrates of DPP-4 whereas others bind to the catalytic site without being degraded

We have postulated (15) that increased breakdown of cholesterol esters from VLDL + LDL as a consequence of L-carnitine-induced catabolism of fatty acids, combined with transfer of cholesterol esters from VLDL + LDL to HDL, probably mediated by cholesteryl ester transfer protein 33, 34 , leads to increased cholesterol reverse transport and excretion 35, 36

Luke B, Brown MB, Wantman E, et al