does semaglutide lose efficacy over time this (Wegovy) study really show four-year sustained weight loss? Part 2 The Pros and Cons of

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Phase 2 Side-Effect Frequencies at 4.5 mg/week (Lancet 2021) Side Effect Nausea Incidence at 4.5 mg/week 47% Side Effect Injection-site reactions Incidence at 4.5 mg/week 43% Side Effect Constipation Incidence at 4.5 mg/week 21% Side Effect Fatigue Incidence at 4.5 mg/week 20% Side Effect Allergic reactions (any) Incidence at 4.5 mg/week 10% Side Effect Vomiting Incidence at 4.5 mg/week 8% Side Effect Loose stools Incidence at 4.5 mg/week 7% Side Effect Headache Incidence at 4.5 mg/week 7% Side Effect Indigestion Incidence at 4.5 mg/week 4% Incidence was lower at lower doses

You will likely hear a clicking sound or see the dose counter return to zero

[19] Eli Lilly and Company (2021) A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight (SURMOUNT-1)