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Protection of the gastric mucosa: Originally identified for its gastroprotective effects, BPC-157 maintains mucosal integrity by stabilizing cellular junctions and reducing oxidative stress

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This review focuses on the significance of oxidative stress in SARS-CoV and SARS-CoV-2 infections, particularly as it relates to viral interaction with ACE2, viral infection as a result of disulfide-thiol balance, the role of ACE2 in lowering oxidative stress, the impact of reduced/oxidized nicotinamide dinucleotide phosphate (NADPH/NADP + ) equilibrium on ACE2, and how thioredoxin (TRX) and protein disulfide isomerase (PDI) affect the oxidation state of ACE2