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Newer agents like survodutide , orforglipron , or mazdutide are in various stages of development and clinical use, and retatrutide (a triple agonist targeting GIP, GLP-1, and glucagon receptors) shows even greater weight loss potential than tirzepatide in early trials

Based on BMI alone, some very muscular people would qualify for GLP-1 treatment under current FDA guidelines, even though they dont need it

But does where you inject GLP-1s make a difference

Activated microglia inflict damage on oligodendrocytes through the release of pro-inflammatory cytokines such as IL-1, IL-6, TNF-, and interferons, alongside phagocytic activity, and antigen presentation to CD 4+ T cells via MHC class II [270]