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The anti-inflammatory signaling that protects heart and kidney tissue may simultaneously reduce the systemic inflammation driving psoriasis, offering a dual benefit mechanism that extends far beyond simple calorie restriction

In clinical practice, SGLT2 inhibitors are often initiated first due to their oral administration and broader reimbursement, with GLP-1 receptor agonists subsequently added to address persistent hyperglycemia, excess body weight, or residual albuminuria [84,85]

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