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"These specific defects should be included in public health educational information to encourage more women to quit smoking before or early on in pregnancy, and to particularly target younger women and those from lower socioeconomic groups, in which smoking prevalence is greatest." The authors also called for more research into whether the risk of lifelong physical abnormalities in a child might encourage more women to quit.

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This limitation emphasizes the need to interpret interpolated trends with caution, particularly in data-deficient regions