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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Fitzpatrick AM

When overproduction of acetyl-CoA occurs in muscle during intensive exercise, this process ensures the replenishment of free CoA to facilitate pyruvate metabolism, but when exercise ends, transacetylation of acetylcarnitine provides acetyl-CoA for the Krebs cycle

The peptide has also never been characterized in humans the way an approved drug is: there is no established human pharmacokinetic profile, no dose-ranging efficacy study, and no long-term safety dataset