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Allelic affinity for different peptides directly influences which self-peptides will be produced and how likely it is that they will be recognized by T cells

To protect long-term health, women using medications like tirzepatide are encouraged to prioritize resistance training and high protein intake to ensure the weight lost is primarily fat, not muscle

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Patients carrying certain variants may experience more pronounced weight loss and blood pressure reduction, requiring earlier or more aggressive medication adjustments compared to those with different genetic profiles