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Clinical and preclinical single-dose pharmacokinetics of VIR-2218, an RNAi therapeutic targeting HBV infection

In the SURMOUNT-1 trial, tirzepatide 15 mg produced a mean weight reduction of 22.5% over 72 weeks in adults without diabetes, highlighting the potential value of multi-receptor metabolic therapy

These isoforms have distinct cellular roles but possess high sequence identity (66%) and comparable enzyme properties