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We ensured that three essential conditions for MR studies were fulfilled: the selected single-nucleotide polymorphisms (SNPs) correlated significantly with the exposure variable, were unrelated to any potential confounding factor, and were related solely to the risk of laryngeal cancer development as a result of smoking

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This can lead to ROS production and the release of damage-associated molecular patterns (DAMPs), which are pro-inflammatory molecules ( 32 )