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Down-regulation of inducible nitric oxide synthase (iNOS) in AD-model mice, and subsequent decrease in NO, has been associated with rescue of cognitive function, reduction in Ab and NFT load, decreased glial activation, and attenuated neuronal loss [9-11]

Research indicates that AOD-9604 may act, at least in part, through beta-3 adrenergic receptor (3-AR) signaling a pathway tightly associated with fat oxidation in visceral and brown adipose tissue

Furthermore, mutation of the isocitrate dehydrogenase 1 gene in low-grade gliomas causes production of D-2-hydroxyglutarate, a steric analogue of glutamate

Format: Powder (salt form) Compound class: Small molecule (NNMT inhibitor)