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Tranexamic acid blocks the plasmin pathway that triggers melanocyte activation after inflammation, which is a separate mechanism entirely

MELATONIN RELEASE Postsynaptic receptors located in the innervating pituitary, superior cervical ganglion regulate melatonin release

Conclusively, these data reveal the acute immune attacks by macrophages and T cells during relapses, whereas chronic progression of the disease is associated with B cell infiltration